Indoor atmospheres and other confined spaces are often contaminated by tobacco smoke which is inhaled involuntarily by both smokers and nonsmokers. It is called involuntary smoke inhalation or passive smoking. It is now recognized as a cause of lung cancer in nonsmokers.

Accumulation of fat in the liver of the alcoholics result from the combination of impaired fatty acid oxidation, increased uptake and esterification of fatty acids to form triglycerides and diminished lipoprotein biosynthesis and secretion. Lipoproteins may also accumulate in the liver. Fatty liver syndrome is a condition of permanent damage to the structure and functioning of liver cells.