science
Grade-10
Easy

Question

Alkyl bases are induced in DNA by which chemical mutagen?

  1. Deaminating agents

  2. Alkylating agents.

  3. Hydroxylating agents.

  4. None of the above.

hintHint:

Cisplastin, nitrogen mustard are common examples.

The correct answer is:

Alkylating agents.


    • Alkylating agents introduce alkyl bases  into DNA
    • These agents inhibit cell division and are used in treatment of cancer
    • The agents cause crosslinking of the DNA strands or by replacing hydrogen atoms of DNA with alkyl groups
    • The alkyl agents are used in the treatment of cancer
    • Cisplastin, Carboplastin, nitrogen mustard are common alkylating agents

    • The alkylating agents helps in crosslinking of DNA which cannot replicate 
    • Other mechanism is by replacing hydrogen atoms of DNA with alkyl groups which cannot be repaired by the cell

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