science
Grade-10
Easy

Question

In sickle cell anemia amino acid______ is formed as a result of point substitution.

  1. Glutamine

  2. Asparagine

     
     
  3. Valine.

  4. Leucine.

Hint:

In sickle cell anemia, the amino acid valine is formed as a result of point substitution.

The correct answer is:

Valine.


    • Sickle cell anemia is caused by the replacement of a single amino acid of valine in the beta chain with glutamic acid due to a nucleotide deficiency that causes abnormal production of the beta chain of hemoglobin S.
    • Abnormal hemoglobin chains form polymers upon deoxygenation, resulting in the characteristic sickle cell.

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