science
Grade-10
Easy

Question

Point Mutation is caused by:

  1. Base analogs.

  2. Alkylating agents.

  3. Hydroxylating agents.

  4. Metal ions.

hintHint:

Substitution of a nucleotide is one of the causes for point mutation.

The correct answer is:

Base analogs.


    • Point mutation refers to substitution of one base by another
    • The substitution of a bas occurs due to structural similarities between a base and the analogue
    • Point mutation can be classified into transition and transversion mutations
    • Base analogues have structure similar to bases found in DNA
    • Common base analogue include 5BromoUracil and 2AminoPurine
    • 2AminoPurine has structure similar to purines (adenine and guanine)

    • Point mutation can be caused due to substitution by a base analogue or due to exposure to ionizing radiations as well
    • Point mutation can also be due to deletion or insertion of a base pair

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