science
Grade-11
Easy

Question

Select the correct match

  1. Down syndrome – 21st chromosome
     
  2. Sickle cell anemia- X chromosome 
  3. Hemophilia –Y chromosome 
  4. Sickle cell anemia- Y chromosome

hintHint:

Intellectual capacity of the individual is lost in this type of genetic disorder

The correct answer is: Down syndrome – 21st chromosome

 


    Genetic disorder is a result of harmful mutation. Normal protein production is impaired due to change in the DNA sequence of an organism in harmful mutation. The mutation is caused due to mistake during DNA replication or due to exposure of the organism to external agents called mutagens.
    Some common examples of genetic disorders include Down syndrome, Klinefelter syndrome, Turner syndrome, Cystic fibrosis, Sickle cell anemia and many more.
    Genetic disorders can be broadly classified into chromosomal, multifactorial and monogenic in nature.
    Chromosomal genetic disorders lack the general structure of the DNA or the chromosome, resulting in a duplicated or missing genetic material. Down syndrome is an example of this type with 3 copies of chromosome 21 (trisomy).
    Multifactorial type is caused due to combined effects of exposure of the individual to the mutagens.
    Monogenic disorders are caused due to mutation of single gene. Sickle cell anemia and hemophilia is caused due to change in HBB gene in chromosome 11 and gene mutation in X chromosome, respectively

    • Genetic disorder is a result of harmful mutation
    • Genetic disorders can be classified as chromosomal, multifactorial and monogenic in nature
    • Down syndrome is a chromosomal disorder. The individual will posses 3 copies of chromosome 21. The disorder causes intellectual impairment of the mutant.
    • Sickle cell anemia and hemophilia are examples of monogenic mutations wherein HBB gene chromosome 11 and F8 gene in X chromosome are mutated, respectively.

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    Which of the following can increase the rate of mutation?

    • Mutagen is the agent that causes mutation
    • Mutagens can be classified into physical, chemical and biological mutagens
    • Electromagnetic radiations come under physical mutagens
    • Toxic chemicals like smoke, cosmetic products can be classified under chemical mutagens
    • Viruses and other infectious agents are biological mutagens

    Which of the following can increase the rate of mutation?

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    • Mutagen is the agent that causes mutation
    • Mutagens can be classified into physical, chemical and biological mutagens
    • Electromagnetic radiations come under physical mutagens
    • Toxic chemicals like smoke, cosmetic products can be classified under chemical mutagens
    • Viruses and other infectious agents are biological mutagens

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    Genetic mutations can be...

    • Mutation is caused due to alteration in the normal gene sequence of an organism
    • Beneficial mutation has positive effect on the organism and helps to thrive in difficult situations as well. Example for beneficial mutation is development of lactose tolerance in humans.
    • Harmful mutation results in genetic disorders or cancer
    • Silent mutation show no effect on the organism

    Genetic mutations can be...

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    • Mutation is caused due to alteration in the normal gene sequence of an organism
    • Beneficial mutation has positive effect on the organism and helps to thrive in difficult situations as well. Example for beneficial mutation is development of lactose tolerance in humans.
    • Harmful mutation results in genetic disorders or cancer
    • Silent mutation show no effect on the organism

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    What do gene mutations change?

    • DNA or deoxyribonucleic acid is the genetic material of all eukaryotic organisms and few prokaryotic organisms
    • Mutation refers to change in the sequence of genetic material of an organism
    • RNA or ribonucleic acid is genetic material of few viruses alone
    • Lipids and proteins provide energy and form building blocks of life, respectively. They do not have any role in genetic mutation.

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    • DNA or deoxyribonucleic acid is the genetic material of all eukaryotic organisms and few prokaryotic organisms
    • Mutation refers to change in the sequence of genetic material of an organism
    • RNA or ribonucleic acid is genetic material of few viruses alone
    • Lipids and proteins provide energy and form building blocks of life, respectively. They do not have any role in genetic mutation.

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    Are all mutations bad?

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    • Condition where the normal gene sequence of an organism is altered is called mutation
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    • Evolutionary changes can be attributed as an example of beneficial mutation
    • Cancer, Antibiotic resistant bacteria and many more are examples of harmful mutation

    Are all mutations bad?

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    • Not all mutations are harmful
    • Condition where the normal gene sequence of an organism is altered is called mutation
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    • Evolutionary changes can be attributed as an example of beneficial mutation
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    What are the building blocks of proteins called?

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    What are the building blocks of proteins called?

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    amino acids are known as building blocks of proteins.

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    • Change in gene sequence is termed as mutation
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    Any change in the sequence of DNA is...

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    • Change in gene sequence is termed as mutation
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    • Mutagens can be physical, chemical or biological in nature
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    What do we use pedigrees for?

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    • Pedigree chart helps to analyze the traits of individuals in a family
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    • Pedigree chart is represented in the form of boxes and circles (males and females, respectively)
    • Normal, carrier and affected individuals can be distinguished in a pedigree chart

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    • Females carry XX chromosome
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    In order to trace occurrence of a trait through several generations of a family, you could create a ____________.

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    In order to trace occurrence of a trait through several generations of a family, you could create a ____________.

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    • A karyotype chart represents the image of an individuals chromosome
    • Chromosomal map represents the genes present in a chromosome
    • Hemoglobin is a protein present in red blood cell
    • Pedigree chart is a tool used to analyze the passage of traits between generations

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    Which chromosome is affected by hemophilia?

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    • Hemophilia is a blood disorder
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    • The genes for producing clotting factors are present in X chromosome

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    What is the name of the protein that is not normal in people with sickle-cell disease?

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    • Sickle cell disease is a medical condition where the Red Blood Cells loses its normal shape 
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    Which disease or disorder causes people to have abnormal hemoglobin?

    • Disorder or disease associated with hemoglobin causes anemia
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    • The RBCs with "S" hemoglobin become rigid and sickle shaped with inability to transport gases, resulting in anemia
    • Hemophilia is the disorder due to deficiency of clotting factors 
    • Cystic fibrosis affects respiratory system
    • Females possessing single X chromosome are termed with a medical condition called Turner syndrome

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    • Disorder or disease associated with hemoglobin causes anemia
    • In sickle cell anemia, the individual posses an altered "S" hemoglobin causing the RBCs to alter its shape
    • The RBCs with "S" hemoglobin become rigid and sickle shaped with inability to transport gases, resulting in anemia
    • Hemophilia is the disorder due to deficiency of clotting factors 
    • Cystic fibrosis affects respiratory system
    • Females possessing single X chromosome are termed with a medical condition called Turner syndrome

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    Which disease or disorder is the result of having an extra chromosome?

    • Down syndrome is also termed as trisomy 21
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    • Trisomy 21 is caused due to improper separation of chromosomes during meiosis
    • Cystic fibrosis is an autosomal recessive disorder
    • Color blindness is an autosomal dominant disorder
    • Hemophilia is a monogenic genetic disorder

    Which disease or disorder is the result of having an extra chromosome?

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    • Down syndrome is also termed as trisomy 21
    • Individuals posses an extra chromosome at 21 position
    • Trisomy 21 is caused due to improper separation of chromosomes during meiosis
    • Cystic fibrosis is an autosomal recessive disorder
    • Color blindness is an autosomal dominant disorder
    • Hemophilia is a monogenic genetic disorder

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    Which disease or disorder is caused by the inheritance of two mutated alleles?

    • Cystic fibrosis results in breathing disorder of the affected individual due to increased thick mucus secretion
    • The disorder is caused due to alteration in CFRT gene
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    • Other disorders mentioned are not autosomal recessive in nature

    Which disease or disorder is caused by the inheritance of two mutated alleles?

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    • Cystic fibrosis results in breathing disorder of the affected individual due to increased thick mucus secretion
    • The disorder is caused due to alteration in CFRT gene
    • It is a type of autosomal recessive disorder, having both copies of gene altered in a cell
    • Other disorders mentioned are not autosomal recessive in nature

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